This would be an awesome feature, for starters as a user I am already familiar with the concept of profiles like google chrome has, I use one for work and one for home. Both have different set of extensions and plugins that I use.
Having a similar concept in Atom would be a real treat. During the day when I am at work, I have a different SCM manager that’s internal to my org, we have developed a package for Atom. And use a ton others that’s related to tech stack that I use at work.
So yeah, something like profiles should be a real life saver.